Cancer risk in heterozygotes for ataxia-telangiectasia
نویسندگان
چکیده
منابع مشابه
Public health burden of cancer in ataxia-telangiectasia heterozygotes.
Knowing that mutations of a specific gene predispose to certain cancers is an important step toward more effective preventive or therapeutic measures for those cancers. The history of ataxia-telangiectasia (A-T) research illustrates how advances in genetic and molecular genetic technology are clarifying and quantifying the role of mutations at this genetic locus in common diseases and mortality...
متن کاملp53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.
Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder characterized by radiosensitivity, genomic instability, and predisposition to cancer. A-T is caused by biallelic mutations in the ataxia-telangiectasia mutated (ATM) gene, but heterozygous carriers, though apparently healthy, are believed to be at increased risk for cancer and more sensitive to ionizing radiation t...
متن کاملCancer in homozygotes and heterozygotes of ataxia-telangiectasia and xeroderma pigmentosum in Britain.
We have documented mortality and cancer incidence in the families of 67 patients with ataxia-telangiectasia and 48 patients with xeroderma pigmentosum resident in Britain. For both diseases, parents of patients are obligate heterozygotes and grandparents have a probability of heterozygosity of 0.5. Fourteen ataxia-telangiectasia patients had died by June 30, 1986. This was a significant excess ...
متن کاملGenetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk.
To evaluate the role of genetic polymorphisms of ataxia telangiectasia mutated (ATM) in the etiology of breast cancer, a hospital-based case-control study was conducted in Korea. Nine-hundred ninety-six histologically confirmed incident breast cancer cases and 1,181 cancer-free controls were recruited in Seoul between 1995 and 2003. Genotypes of the ATM polymorphisms-5144A > T, IVS21 + 1049T > ...
متن کاملGenetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk.
The ataxia telangiectasia mutated (ATM) gene is known to be activated by DNA damage and involved in cell cycle arrest, apoptosis and DNA repair. Therefore, ATM gene polymorphisms may act as important factors predicting individual susceptibility to lung cancer. To evaluate the role of ATM gene polymorphisms in lung cancer development, genotypes of the ATM polymorphisms, -4518A>G, IVS21-77C>T, IV...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2001
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.1329